Genomics

Leading clinical genomics revolution

DNA profiling & Genetic profiling are the sciences of identifying individual person’s genetic characteristics by analyzing personal DNA or DNA profile. With DNA profiling & genetic profiling, researchers are able to individually map a person's DNA, providing doctors and healthcare providers insight information about the person's risks and abilities in terms of health, performance and potential for developing certain diseases. Main focus for our genomic profiling services is to provide the most beneficial, individual and even lifesaving treatment options for severe illnesses, especially in management of cancer.

 

  • DNA, or deoxyribonucleic acid, is the hereditary material in human which carries genetic information. Nearly 99.9% DNA in all individuals is same.
  • The information in DNA is stored as a “code” called nucleotides, which are arranged in two long strands that form a spiral called a double helix.
  • As cells grow in our body and divides, DNA replicates to transfer the exact genetic information to the new cell. Each strand of DNA serves as a pattern for duplicating the sequence of bases. If DNA duplicates abnormally, it is called a genetic mutation, which is the cause of most of the diseases.
  • Genomics is the study of all the genes of a cell, the DNA, mRNA and all protein levels.
  • Genomics studies the entire individual’s genetic chain and it is the most advanced diagnostic test available.
  • Genomics used worldwide in the leading institutes in field of cancer management. Beside cancer management, genetic profiling can give valuable information to avoid and/or treating diseases like heart diseases, diabetes, neurological disorders, psychiatric disorders etc.

Cancer Genomics & Targeted Therapy

Cancer is not a single disease. It is a group of more than 200 different diseases caused by individual genetic changes.

Patients with same type of cancer, might have different type of genetic changes which drives the disease to progress. This is the reason behind why other cancer patients, even if suffering from same cancer, needs to be treated differently than other individual.

Conventionally patients with same cancer are treated with same protocol. This approach doesn’t work in cancer as it is a much more complex disease driven by individual genetic mutations.

Only 1 in 4 cancer patient benefits from mainly used “one size fits all”- approach while remaining patients experience poor benefits from the treatment and poor prognosis, more side effects, financial loss etc.

The Cancer Genomics test identifies the driving genetic changes of the individual, to benefit from targeted options as per their personal genetic profile.

 

Targeted therapy directly alters the driving mutation in cancer progression. Therefore targeted therapy is much more beneficial than conventional therapy.

Clinico- genetics solutions translate genome sequencing data into evidence- based treatment strategies and assist oncologists to overcome the challenge of determining the right treatment, since the very beginning.

Cancer genomic test helps to:

  • Plan precise chemotherapy and/or biological treatment as per your genetic profile
  • Reduce treatment cost and time by eliminating trial & error
  • Reduce treatment related adverse effects
  • Reduced hospital stay
  • You will get evidence based treatment options analyzed from your individual genetic profile and medical history, which helps your caregivers to make decisions about the most optimal targeted treatment.

Personal Genomics

Personal genomics test analyzes DNA and identify risk of various diseases based on the presence of genetic mutations in the human body.

Personal Genomics test gives valuable and individual information about 48 000+ diseases and gives ways to prevent these diseases by altering the lifestyles and environmental factors.

Personal Genomics Testing identifies genes driving cancer, heart disease, diabetes, Alzheimer’s, multiple sclerosis, schizophrenia, neonatal diseases and many more...

Collaboration with Myriad Genetics. You will benefit from the same technology what is used in leading institutes in the world, like Mayo Clinic, The Genome Institute of Washington University, MD Anderson Cancer Center and many more…

Myriad Genetics is a leading Genetics company based in United States of America. Myriad invented f.e. BRCA gene and its association with Breast Cancer.  More than 65000 doctors across 85 countries trust Myriad for genetic testing.

“Genetic profiling results do not necessary have a negative implication, and predictive DNA profiles do not suggest that one will definitively develop a disease. They do however indicate that there is an increased likelihood of a particular condition, especially in combination with other factors such as a family history, environment, nutrition and other personal health factors such as weight, blood pressure, etc. Possessing this knowledge can help people with hereditary risk factors make lifestyle choices that benefit their overall health and reduce their chances of developing a serious health condition just because it is "in their genes".

 

Why get a Personal Genomics test?

Family History

  • If diseases like cancer, heart conditions, diabetes, brain
    disorders, etc. runs in your family, then you might have a risk to develop same disease
  • Finding your risk to develop certain diseases, will help you make lifestyle changes on time
  • Personal Genomic test is a once- in- a- lifetime test because your DNA never changes

Lifestyle

  • Lifestyle choices like bad food habits, smoking, sedentary work, lack of sleep, stress etc. makes
    you prone for various diseases like cancer, heart disease etc.
  • One will get diseases or not, depends on individual genetic profile, f.e. if you have mutation in BRCA gene and you are a smoker, there is 25% more chances of developing lung cancer.
  • Even if you are living a healthy life, you may be at risk because of you have genetic mutation, family history or other unknown risk factors.

Invest in your future

  • Prevention is always better than a cure - Personal Genomic helps you
    to prevent major diseases and helps you to make right lifestyle choices and reduce your healthcare costs, when needed. With the help of Personal Genomics Test, you can improve and secure your quality of life and improved your physical and social wellbeing now and for the future.
  • The Personal Genomics Test gives you peace of mind by replacing fear and uncertainty about your health with scientific knowledge and helps you to take proper action in health and lifestyle related needs as required and on time.

PharmacoGenomics – The Future of Medicine

Pharmacogenomics is one the latest special areas in the fields of medical science. Pharmacogenomics is about how our personal genes affect at our individual response to medication. This relatively new field of medicine, combines pharmacology (the science of drugs) and genomics (the study of human genes and their functions) to develop and use only effective, safe medications and doses that will be tailored by a person’s individual genetic profile.

 

Many drugs that are currently available are used as “one size fits all,” but they don't work the same way for everyone. It is difficult, actually almost impossible to predict who will benefit from a medication, who will not respond at all, and who will experience negative side effects (called adverse drug reactions). Adverse drug reactions are one of the significant causes of hospitalizations and deaths all over the world, especially in the long term use of medication and in the cases where the proper response to the medication cannot be verified with certainty. With the knowledge gained from individual genomic profile, doctors will get valuable information how inherited differences in genes affect the body’s response to medication. Information from genetic differences will be used to help in assessment whether medication will be effective for a particular person and to help prevent adverse drug reactions and to provide the most beneficial treatment for the patient.

Pharmacogenomics allows the development and use of more tailored drugs to treat wide range of health problems, including cardiovascular diseases, Alzheimer’s disease, cancer, HIV/AIDS etc. with more precise, effective and safer approach. Pharmacogenomics uses information from person's genetic profiling, or genome study, to choose the drugs and drug doses that are more likely to work best for the particular person. Genomic research has changed this "one size fits all" approach and opened the doors to more personalized treatment approaches how to use and develope drugs from the individual human body perspective.

Depending on your genetic profile, some drugs may work more or less effectively for you than they do to other people. Likewise, some drugs may produce more or fewer side effects for you, than to someone else. With the help of latest developments in pharmacogenomics, doctors will be more able to use information from your genetic profile to choose those drugs and drug doses that will offer the best chance of helping you.

Beside supporting your targeted treatment and avoiding even lethal side effects, pharmacogenomics may also help you to save time and money. By using information from your genetic profile, doctors will get more accurate information to help them to avoid the trial-and-error approach by giving you various drugs that might not work at all, until they find the right one for you. This goes especially in treatment of cancer. Using pharmacogenomics, we will provide you and your doctor vital information to choose the "best-fit" drug for your optimal treatment from the first diagnosis.

Life Genomics

Personalized nutrition aims to prevent the onset and development of chronic diseases by targeting dietary recommendations to an individual's genetic profile. Our own genes and diet interactions that affect our metabolic pathways relevant to disease risk are continuously being uncovered. Discoveries in the field of nutrigenomics demonstrate that some individuals may benefit from adhering to different dietary guidelines than others, depending on their genotype. Knowledge of your genomic information could help you to prevent the risk of developing diseases.

Variability between individuals in response to dietary intervention is a well- documented occurrence in nutrition research and practice. The effect of diet modification on health- related markers such as blood cholesterol, body weight and blood pressure can differ significantly between individuals for several reasons. These differences partially account for the limited effectiveness of the current one- size- fits- all and all- population- based model of nutritional guidance for health promotion. Factors such as age, sex, physical activity and smoking are known to affect one's response to diet, but the influence of genetics is becoming an increasingly important.

Nutrigenomics is the study of the relationship between genes and diet, and it is used as an umbrella term for two complimentary approaches: how nutrients affect our gene function and how genetic variation affects nutrient response. The latter is referred to as nutrigenomics and includes the study of how genetic variation affects food intake and eating behaviors, in addition to the biological response to nutrients and food bioactives.

Recent advances in nutrigenomics have shown that some individuals benefit more by following different dietary recommendations than others based on their individual genotype. This method to personalize dietary recommendations based on 'responders' and 'nonresponders' is one of the primary goals of nutrigenomics. Basically individual's personal genomic information will give information what person should intake and what to avoid to maintain weight control and prevent diseases. Personalized nutrition is useful in both the prevention and treatment of chronic diseases by tailoring dietary advice and designing targeted dietary interventions to an individual's unique genetic profile. Nutrigenomics will help you to understand why “she” loses weight and keeps more fit than you even with the same diet and exercise program as you.

Research Possibilities

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